Cyclooxygenase-2 Regulates Apoptosis in Rat Epididymis Through Prostaglandin D21
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چکیده
منابع مشابه
Cyclooxygenase 2-derived prostaglandin E2 regulates the angiogenic switch.
T he first evidence of a potential relationship between the cyclooxygenase 2 (COX-2) enzyme and human cancers was reported in 1994, when COX-2 mRNA levels were found to be markedly elevated in colorectal carcinomas (1). Several subsequent reports verified and extended these findings (2). COX-2 (prostaglandin endoperoxide synthase) converts arachidonic acid to bioactive lipids, including prostag...
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Paraquat is a commonly used herbicide in many countries which can lead to systematic poisoning on exposure, In this study, paraquat (PQ)-induced changes in the expression of Cyclooxygenase-2 (COX-2) along with biochemical and histopathological changes in the lungs, liver and kidneys were studied. Twenty four male Wistar rats (180-200 g) were exposed either against saline as control group or var...
متن کاملParaquat Exposure Up-regulates Cyclooxygenase-2 in the Lungs, Liver and Kidneys in Rats
Paraquat is a commonly used herbicide in many countries which can lead to systematic poisoning on exposure, In this study, paraquat (PQ)-induced changes in the expression of Cyclooxygenase-2 (COX-2) along with biochemical and histopathological changes in the lungs, liver and kidneys were studied. Twenty four male Wistar rats (180-200 g) were exposed either against saline as control group or var...
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The functional significance of cyclooxygenases (COX-1 and -2), the key enzymes that convert arachidonic acid (AA) to prostaglandins (PGs) in brain, is unclear, although they have been implicated in cellular functions and in some neurologic disorders, including stroke, epilepsy, and Alzheimer's disease. Recent evidence that COX-2 is expressed in postsynaptic dendritic spines (which are specializ...
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Cyclooxygenase-2 (COX-2) is constitutively expressed and highly regulated in the thick ascending limb (TAL). As COX-2 inhibitors (Coxibs) increase COX-2 expression, we tested the hypothesis that a negative feedback mechanism involving PGE(2) EP3 receptors regulates COX-2 expression in the TAL. Sprague-Dawley rats were treated with a Coxib [celecoxib (20 mg·kg(-1)·day(-1)) or rofecoxib (10 mg·kg...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2002
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod66.2.374